Health databases & datasets: US

HDB-0001

MIMIC-IV

MIT Laboratory for Computational Physiology De-identified electronic health records from patients admitted to Beth Israel Deaconess Medical Center, covering ICU and emergency department stays from 2008 onward. The de facto standard dataset for clinical machine learning research, with vitals, labs, medications, procedures and linked clinical notes modules. Open dataset Credentialed HDB-0002

eICU Collaborative Research Database

MIT LCP / Philips Healthcare Multi-center ICU database from the Philips eICU telehealth program, covering 200,000+ admissions across hospitals in the United States. Complements MIMIC with multi-center generalizability for critical care research. Open dataset Credentialed HDB-0003

NHANES

CDC / National Center for Health Statistics The National Health and Nutrition Examination Survey combines interviews, physical examinations and laboratory tests on a representative sample of the US population, released in continuous two-year cycles since 1999. A workhorse dataset for epidemiology and public health research. Open dataset Open access HDB-0004

SEER Cancer Registry

National Cancer Institute The Surveillance, Epidemiology, and End Results program collects cancer incidence, treatment and survival data from population-based registries covering roughly half of the US population. The reference source for US cancer statistics. Open dataset By application HDB-0006

All of Us Research Program

National Institutes of Health NIH's flagship precision-medicine cohort, enrolling a diverse US population with surveys, EHR data, genomics and wearable data. Researchers work in a cloud-based Researcher Workbench with tiered access levels. Open dataset Credentialed HDB-0007

HCUP Databases

Agency for Healthcare Research and Quality The Healthcare Cost and Utilization Project family of databases (including the National Inpatient Sample) captures hospital inpatient, emergency and ambulatory encounters across the US. The standard source for hospital utilization, cost and outcomes research; datasets are purchased with a data use agreement. Open dataset Paid HDB-0008

openFDA

US Food and Drug Administration Open APIs and bulk downloads for FDA regulatory data: drug adverse events (FAERS), drug labels, recalls, device reports and more. Free, well-documented JSON APIs that power pharmacovigilance and regulatory analytics tools. Open dataset Open access HDB-0009

NPPES NPI Registry

Centers for Medicare & Medicaid Services The public registry of every US healthcare provider and organization with a National Provider Identifier, searchable via API and downloadable as monthly bulk files. The foundation layer for US provider directories and healthcare B2B data products. Open dataset Open access HDB-0013

Definitive Healthcare

Definitive Healthcare, LLC Commercial healthcare intelligence platform profiling US hospitals, health systems, physicians and payers, with affiliations, technology installs, claims-based volumes and executive contacts. Widely used by sales, marketing and strategy teams selling into healthcare. Commercial provider Paid HDB-0015

Ampliz

Ampliz Healthcare-focused B2B contact and intelligence platform covering physicians, executives and facilities in the US, positioned for SMB and mid-market sales teams. Provides verified emails, direct dials and firmographic data with healthcare-specific segmentation. Commercial provider Paid HDB-0016

Komodo Health

Komodo Health Komodo Health operates Healthcare Map, a de-identified patient-level data platform combining over 1 trillion linked records from 330+ million patients, refreshed daily. Access requires enterprise contract through direct engagement with Komodo's sales and solutions team. Commercial provider By application HDB-0017

Truveta

Truveta (collaborative health systems) Truveta Data provides daily-updated electronic health records and claims from 130+ million patients sourced directly from member health systems. Organizations access data through Truveta Evidence (trusted research environment) or Truveta Intelligence (query-based analysis tool), with expert-guided research services available. Commercial provider By application HDB-0018

Optum Life Sciences (Market Clarity / Clinformatics)

Optum (UnitedHealth Group) Optum offers Market Clarity and Clinformatics Data Mart, de-identified repositories containing claims and clinical data from 80+ million unique patient lives with 20,000+ mapped clinical variables and over 1 billion prescriptions. Access is provided through licensed commercial agreements with Optum's sales organization. Commercial provider Paid HDB-0019

Merative MarketScan

Merative MarketScan is a proprietary United States claims database containing de-identified commercial and Medicaid insurance claims data supporting real-world evidence research. Academic institutions, pharmaceutical companies, and researchers access the data through Merative's workspace tools and research services, with specialized dissertation support available. Commercial provider By application HDB-0020

HealthVerity

HealthVerity HealthVerity Marketplace aggregates de-identified healthcare data from 75+ sources covering 340+ million individuals, including claims, EHR, labs, pharmacy, consumer data, and social determinants of health. Organizations access datasets through the marketplace via custom licensing agreements with configurable data selection. Commercial provider By application HDB-0021

Datavant

Datavant Datavant's Health Data Nexus consolidates de-identified clinical records, claims, and patient charts into unified longitudinal patient views for healthcare organizations. Payers and providers access structured and enriched data through the cloud-based platform for applications including risk adjustment, quality programs, and population health analytics. Commercial provider By application HDB-0022

Clarify Health

Clarify Health Solutions Clarify Health's Atlas Platform provides underlying database covering 300+ million patient lives with longitudinal records, negotiated pricing rates, and machine learning-trained outcomes predictions. Health systems and payers access the data through the Meridian product for referral network optimization and care pathway analytics. Commercial provider By application HDB-0023

Symphony Health (ICON)

Symphony Health (ICON plc / HealthVerity) Symphony Health's Integrated Dataverse provides de-identified medical, hospital, prescription, and demographic claims data linked at the patient level. The platform is now integrated into HealthVerity's broader ecosystem, offering access to specialty data products and analytics through the HealthVerity Marketplace. Commercial provider By application HDB-0027

Doximity

Doximity Inc. Doximity is the largest verified professional network of U.S. healthcare clinicians, operated by Doximity Inc., with over 3 million members including more than 85% of U.S. physicians plus nurses, pharmacists, and other healthcare professionals. The platform provides a professional directory, secure messaging, and clinical communication services; registration and use are free for verified U.S. healthcare professionals, with additional enterprise services available to healthcare organizations. Commercial provider Free registration HDB-0028

CarePrecise

CarePrecise CarePrecise is a U.S. healthcare provider database containing information on more than 9.3 million providers, including physicians, dentists, pharmacists, nurses, hospitals, and clinics, compiled from CMS, federal, and other authoritative sources. The platform serves researchers, healthcare organizations, and commercial entities for workforce analysis and provider outreach through paid subscription packages with varying data comprehensiveness. Commercial provider Paid HDB-0040

dbGaP (Database of Genotype and Phenotype)

National Center for Biotechnology Information (NCBI), National Institutes of Health dbGaP is a repository of genotype and phenotype data from human research studies, maintained by the National Center for Biotechnology Information (NCBI) at the National Institutes of Health. The database contains data from over 3,400 studies with over 8 million participants, with some data publicly available and other datasets requiring formal access authorization. Open dataset Open access HDB-0041

Gene Expression Omnibus (GEO)

National Center for Biotechnology Information (NCBI), National Institutes of Health The Gene Expression Omnibus is a public repository for gene expression and epigenomics data from microarray and sequencing experiments, operated by NCBI. It houses over 292,000 studies and 8.6 million samples, which researchers can search, download, and analyze through web-based tools or programmatic interfaces. Open dataset Open access HDB-0042

TCGA via NCI Genomic Data Commons

National Cancer Institute (NCI), National Institutes of Health The NCI Genomic Data Commons is a repository and analysis platform for cancer genomics data, including data from The Cancer Genome Atlas (TCGA), which characterized over 20,000 cancer samples across 33 cancer types. Data is accessed through the GDC web portal, API, or data transfer tools, with controlled-access datasets requiring authorization. Open dataset Open access HDB-0045

ClinVar

National Center for Biotechnology Information (NCBI), National Institutes of Health ClinVar is a public archive of human genetic variants and their clinical significance, maintained by NCBI and aggregating submissions from over 3,400 submitters worldwide. Researchers can search, download, and programmatically access information about millions of variants and their relationships to diseases and drug responses. Open dataset Open access HDB-0046

GTEx Portal

Broad Institute, National Institutes of Health The Genotype-Tissue Expression Portal provides tissue-specific gene expression and quantitative trait locus (QTL) data from 54 non-diseased tissue sites across approximately 1,000 individuals, maintained by the Broad Institute with NIH support. Data including raw RNA-seq reads, processed expression matrices, and QTL results are freely accessible through the portal's web interface and API. Open dataset Open access HDB-0048

The Cancer Imaging Archive (TCIA)

National Cancer Institute (NCI) TCIA is a service that de-identifies and hosts large archives of medical images of cancer accessible for public download. The archive contains cancer-related imaging collections organized by disease type, imaging modality, and research focus, supporting research in radiology image analysis. Open dataset Open access HDB-0049

NIH ChestX-ray14

NIH Clinical Center NIH ChestX-ray14 is a publicly available dataset of 112,120 de-identified frontal-view chest radiographs from 30,805 patients, each labeled with 14 thoracic diseases via natural language processing of radiological reports. The dataset serves as a benchmark for developing and evaluating deep learning models for automated chest X-ray interpretation. Open dataset Open access HDB-0050

CheXpert

Stanford ML Group CheXpert is a large dataset comprising 224,316 chest radiographs from 65,240 patients collected from Stanford Hospital, with labels for 14 clinical observations extracted from radiology reports. The dataset is designed for developing and benchmarking algorithms for automated chest radiograph interpretation. Open dataset Free registration HDB-0051

MIMIC-CXR

MIT Laboratory for Computational Physiology MIMIC-CXR is a publicly available dataset of 377,110 chest X-ray images in DICOM and JPEG formats corresponding to 227,835 radiographic studies from Beth Israel Deaconess Medical Center, each paired with free-text radiology reports. Access requires credentialing and completion of research training to comply with HIPAA privacy protections. Open dataset Credentialed HDB-0052

ADNI (Alzheimer's Disease Neuroimaging Initiative)

National Institute on Aging (NIA) ADNI is a longitudinal, multi-center study of Alzheimer's disease featuring data from over 2,500 participants across the United States and Canada, including neuroimaging (MRI, PET), biomarkers, genetic data, and cognitive assessments. The initiative aims to develop and validate biomarkers for early detection and tracking of Alzheimer's disease progression. Open dataset Free registration HDB-0053

OASIS Brains

Washington University School of Medicine OASIS is a project providing four open-access collections of neuroimaging data from over 1,500 subjects spanning lifespan and disease states including normal aging and Alzheimer's disease. The datasets include multiple modalities (T1/T2-weighted MRI, FLAIR, PET) and longitudinal follow-up data from individual subjects. Open dataset Free registration HDB-0056

CMS Data Portal

Centers for Medicare & Medicaid Services (CMS) The CMS Data Portal provides access to administrative claims data, enrollment records, and quality measures for over 160 million Americans covered by Medicare, Medicaid, CHIP, and the Health Insurance Marketplace. Data is available through Public Use Files (free, de-identified) and Research Identifiable Files (restricted access requiring formal application). Open dataset Free registration HDB-0057

CMS Open Payments

Centers for Medicare & Medicaid Services (CMS) Open Payments is a transparency program that tracks financial relationships between pharmaceutical, device, and medical supply manufacturers and physicians and hospitals. The database publishes annually on or by June 30 and includes general payments, research payments, and ownership or investment interests. Open dataset Open access HDB-0058

HealthData.gov

U.S. Department of Health and Human Services (HHS) HealthData.gov is an HHS data portal providing thousands of downloadable health-related datasets from across HHS agencies including health indicators, healthcare quality metrics, inpatient data, and geographic health information. The platform includes a searchable catalog, analytics dashboards, data stories, and APIs for programmatic access. Open dataset Open access HDB-0059

CDC WONDER

Centers for Disease Control and Prevention (CDC), National Center for Health Statistics (NCHS) CDC WONDER (Wide-ranging Online Data for Epidemiologic Research) is an online query system providing access to public health surveillance data including mortality, cancer incidence, HIV/AIDS, tuberculosis, vaccinations, births, and other disease and health event data. Users query county-level and state-level data through fill-in-the-blank web forms with dynamically calculated statistics, charts, and maps. Open dataset Open access HDB-0060

BRFSS (Behavioral Risk Factor Surveillance System)

Centers for Disease Control and Prevention (CDC) BRFSS is a continuous telephone survey system conducted in all 50 states, DC, and three territories that collects state-level data on health-related risk behaviors, chronic health conditions, and preventive service use among U.S. adults. Data from over 400,000 annual interviews are made publicly available through the CDC website and CDC WONDER database. Open dataset Open access HDB-0061

County Health Rankings & Roadmaps

University of Wisconsin Population Health Institute (UWPHI) in partnership with Robert Wood Johnson Foundation County Health Rankings & Roadmaps provides annual county-level health data for nearly every U.S. county measuring health outcomes and health factors including mortality, chronic disease, employment, food access, air and water quality, education, and lifestyle behaviors. Data is accessible through an interactive online portal organized by state and county with downloadable datasets and evidence-based improvement strategies. Open dataset Open access HDB-0062

VAERS (Vaccine Adverse Event Reporting System)

Centers for Disease Control and Prevention (CDC) and Food and Drug Administration (FDA) VAERS is a post-licensure vaccine safety surveillance system jointly administered by CDC and FDA that collects and analyzes reports of adverse events following vaccination from healthcare providers, manufacturers, and the public. The system publishes data through downloadable datasets and an online search interface integrated with CDC WONDER for detecting unusual or unexpected patterns in adverse events. Open dataset Open access HDB-0063

Medicare Part D Prescriber Data

Centers for Medicare & Medicaid Services (CMS) This CMS dataset contains the number of prescription fills and total drug costs paid organized by prescribing National Provider Identifier (NPI), drug brand name, and drug generic name for medications prescribed to Medicare Part D beneficiaries. The dataset is updated annually and is based on CMS administrative claims data from the Chronic Condition Data Warehouse. Open dataset Open access HDB-0074

RxNorm

National Library of Medicine RxNorm is a normalized naming system for generic and branded clinical drugs maintained by the National Library of Medicine, part of the NIH. It provides normalized drug names and links to drug vocabularies commonly used in pharmacy management and drug interaction systems for semantic interoperation. Terminology Open access HDB-0076

UMLS

National Library of Medicine The Unified Medical Language System (UMLS) is a comprehensive repository of biomedical and health terminologies maintained by the National Library of Medicine, part of the NIH. It integrates over 100 medical vocabularies including SNOMED CT, LOINC, and RxNorm to enable interoperability and cross-referencing between different healthcare coding systems. Terminology Credentialed HDB-0157

FDA Sentinel Initiative

FDA (US Food and Drug Administration) The FDA Sentinel Initiative is a distributed system for evaluating the safety and performance of medical products using real-world data from insurance claims, electronic health records, and patient reports covering approximately 138.7 million members. Data remain with their sources (insurance companies, EHR systems, etc.) and are analyzed through a decentralized model that preserves privacy and data security. Research database By application HDB-0158

PCORnet

PCORI (Patient-Centered Outcomes Research Institute) PCORnet is a national research network funded by PCORI that aggregates health data from diverse clinical settings to enable patient-centered comparative effectiveness research and fast, trustworthy evidence generation. The network provides researchers and healthcare organizations with access to comprehensive clinical data and research infrastructure while incorporating patient perspectives in research design. Research database By application HDB-0159

N3C (National COVID Cohort Collaborative)

NIH NCATS (National Center for Advancing Translational Sciences) N3C is a centralized research platform that aggregates de-identified electronic health record data from over 90 institutions into a secure enclave, containing data on over 500,000 patients for COVID-19, Long COVID, and other disease research. Registered researchers can access the data to conduct collaborative studies on multiple disease domains with full data provenance documentation and strong privacy protections. Open dataset Free registration HDB-0162

Framingham Heart Study

Boston University School of Medicine, National Heart, Lung, and Blood Institute (NHLBI) A prospective cohort study that began in 1948 and now includes three generations with more than 15,000 participants and over 2 million biosamples collected over 78 years. Researchers access data through a formal application process via the Research Application Portal, with datasets available for cardiovascular disease, brain aging, metabolism, and genetics. Open dataset By application